Project Background
Titel: MDR in AIS
Minimizing Door to Reperfusion Times in Drip and Ship Model for Patients with Acute Ischemic Stroke (MDRinAIS) aims to optimize the in-hospital workflow for LVO AIS patients transferred to CSCs for MT.
Challenges addressed:
1. Treatment Timeliness: Streamlining the workflow for secondarily transferred patients minimizes time to treatment, preserving brain function, reducing disability and long-term costs.
2. Complex Time-Dependent Stroke Networks Implementation: Optimizing coordination between primary stroke centers (PSCs), CSCs, and healthcare system. Addressing delays in recommended time targets for MT due to transfers, coordination challenges, and admittance procedures at the CSC’s ED.
3. Feasibility and Implementation of Streamlined Pathways: Proposing a direct transfer pathway bypassing CSC’s ED to reduce doorto-groin(DTG)time and improve outcomes. Feasibility depends on available resources.
4. Variations in Healthcare Systems and Practices: Recognizing unique challenges due to variations among different healthcare systems, and considering evidence-based strategies adaptable to diverse settings. Facing with factors such as cultural differences, economic sustainability and benefits for healthcare systems.
5. Technological Advancements and Implementation: Acknowledging telemedicine potential in streamlining AIS care workflows. Addressing technological literacy among healthcare providers, system integration, and data privacy. The insights gained will be applicable to different clinical settings, ultimately improving services for all patients.
6. Resource Allocation Optimization: Implementing distributed health and care models to optimize resource allocation in time-sensitive and critical settings such as stroke care. Alleviating burden on emergency care facilities, enhancing stroke care delivery through timely interventions and continuous monitoring. Improving the efficiency of healthcare resources and patient outcomes, with consequent cost savings.
Project Facts
Duration
03/2024 to 03/2027 (36 month)
Programme
European Partnership on Transforming Health and Care Systems (THCS)
European Union under the Horizon Europe Framework Programme –
Grant Agreement No. 101095654 (FFG grant agreement No. 50773503).
Identification Code
FP-1127
Project Objectives
Project Structure
WP1 | Project Management & Coordination This work package focuses on coordinating the consortium partners, establishing efficient communication and data sharing mechanisms, and ensuring proper administrative, ethical, and risk management throughout the project. |
WP2 | Evaluation of In-Hospital Workflow WP2 aims to evaluate the timing of the current in-hospital workflows, collect and analyze retrospective clinical and outcome data for comparison. It also seeks to establish criteria for patient selection and study criteria for the retrospective study. |
WP3 | Streamlined In-Hospital Pathway Development WP3 aims to develop and implement a pathway for acute ischemic stroke (AIS) patients eligible for mechanical thrombectomy (MT) to streamline the in-hospital workflow in pilot research settings. |
WP4 | Telemedicine System Selection & Implementation WP4 seeks to implement a telemedicine application for direct and real-time sharing of patient medical data and imaging data in the Lausanne University Hospital (CHUV) and South East Tuscany Local Health Authority (AUSL TSE) stroke pathways. |
WP5 | Prospective Study & Data Analysis WP5 aims at the data collection, preparation, and preprocessing, statistical analysis on prospectively collected data, comparison between clinical settings for timings and outcomes. |
WP6 | Health Economic Impact Evaluation This work package aims to assess the economic sustainability and benefits of the streamlined pathway for AIS management. It also involves collecting policy data related to AIS management workflows in different European contexts. |
WP7 | Communication, Dissemination & Exploitation WP7 aims to disseminate the project findings, develop an exploitation plan, establish an online presence, and engage with initiatives and networks funded by the EU or other national programs. |
Deliverables
WP1 | D1.1 | Project management plan |
WP1 | D1.2 | Risk management and quality plan |
WP1 | D1.3 | Data management plan / GDPR (Version 1) |
WP1 | D1.4 | Ethics framework and guidelines for the ethical committee |
WP1 | D1.5 | Data management plan / GDPR (Version 2) |
WP2 | D2.1 | Case report form for retrospective data collection in clinical settings |
WP2 | D2.2 | Anonymized and compliant sharable database of retrospective data |
WP2 | D2.3 | Sharable database with anonymized retrospective data |
WP3 | D3.1 | Stakeholder analysis report |
WP3 | D3.2 | Standardized approved and coordinated streamlined pathways for AIS patients |
WP3 | D3.3 | Trainings and capacity programs |
WP4 | D4.1 | Implementation and integration of telemedicine system |
WP4 | D4.2 | Evaluation report on the effectiveness of the telemedicine system |
WP5 | D5.1 | Prospective clinical and outcome data report (Version 1) |
WP5 | D5.2 | Prospective clinical and outcome data report (Version 2) |
WP5 | D5.3 | Data collection and case report forms |
WP5 | D5.4 | Prospective clinical and outcome data report (Version 3) |
WP5 | D5.5 | Statistical analysis and modeling summary report |
WP6 | D6.1 | Comparative Analysis Report |
WP7 | D7.1 | Dissemination and Communication plan (Version 1) |
WP7 | D7.2 | Online and media presence (Version 1) |
WP7 | D7.3 | Dissemination and Communication plan (Version 2) |
WP7 | D7.4 | Dissemination and Communication plan (Version 3) |
WP7 | D7.5 | Exploitation strategy |
WP7 | D7.6 | Online and media presence (Version 1) |
WP7 | D7.7 | Engagement summary report |